Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer
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چکیده
منابع مشابه
Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer
The prognosis of patients with Borrmann type IV gastric cancer (Type IV) is extremely poor. Thus, there is an urgent need to elucidate the molecular mechanisms underlying the oncogenesis of Type IV and to identify new therapeutic targets. Although previous studies using whole-exome and whole-genome sequencing have elucidated genomic alterations in gastric cancer, none has focused on comprehensi...
متن کاملClinicopathological features and prognosis of Borrmann type IV gastric cancer.
PURPOSE Borrmann type IV gastric cancer is still detected at an advanced stage and survival rates for these patients remain poor. The purpose of this study was to provide valuable prognostic and surgical information on patients with Borrmann type IV gastric cancer. METHODS We compared the clinicopathological features of Borrmann type IV gastric cancer with those of other types of gastric canc...
متن کاملType IV Borrmann gastric adenocarcinoma: analysis of curative resection results.
OBJECTIVE To evaluate the results obtained with curative resection of Borrmann IV gastric adenocarcinoma (B IV) through the analysis of clinical, surgical and pathological data, identifying which of these prognostic factors were associated with survival. METHODS We retrospectively analyzed 123 patients with B IV gastric adenocarcinoma undergoing surgical treatment at the Department of the pel...
متن کاملPrognostic impact and implications of extracapsular lymph node spread in Borrmann type IV gastric cancer
The purpose of this study was to evaluate the relationship between extracapsular lymph node spread (ECS) and clinicopathology and its influence on the prognosis in patients with Borrmann type IV gastric cancer. Between 2002 and 2014, clinical data were reviewed from 486 patients with Borrmann type IV gastric cancer who underwent curative resection. Of the 486 patients, lymph node metastasis was...
متن کاملClinicopathologic characteristics and prognosis of Borrmann type IV gastric cancer: a meta-analysis
BACKGROUND The clinicopathologic features and surgical treatment strategy of Borrmann type IV (B-4) gastric cancer remains controversial. This meta-analysis was conducted to evaluate the clinicopathologic features of patients with B-4 gastric cancer and to assess whether or not non-curative resection improved prognosis. METHODS PubMed and Embase were searched for relevant articles. Statistica...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2016
ISSN: 2045-7634
DOI: 10.1002/cam4.959